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Original Article 


CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration

Raid Al-Baradie, Stephen Lynch, J Borresen, Jerzy Krupinski, Mark Slevin.

Abstract
Over the past couple of decades there have been no major improvements in the treatment of either acute ischaemic stroke or one of its major complications, neurodegenerative dementia. The majority of promising clinical trials associated with attempts to protect against the debilitating effects of Alzheimer's disease have ended prematurely following exasperation of the condition. Citicoline has been used extensively in patient trials following stroke but strong evidence for its ability to enhance neuroprotection and improve recovery are still lacking. Following our demonstration that this molecule can also enhance angiogenesis/vascularization we hypothesized that it could benefit patients suffering from vascular dementia. Here we describe our recent findings, discuss citicoline signalling and possible links to neurovascular degradation/protection, and consider novel mathematical-biological systems methodology for the identification of potential protective/therapeutic agents against this disease.

Key words: CDP-Choline Neuroprotection, Vascular Remodeling, Vascular Dementia


 
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How to Cite this Article
Pubmed Style

Al-Baradie R, Lynch S, Borresen J, Krupinski J, Slevin M. CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. Majmaah J Heal Sci. 2013; 1(1): 5-10. doi:10.12816/0004765

Web Style

Al-Baradie R, Lynch S, Borresen J, Krupinski J, Slevin M. CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. https://www.mjhs-mu.org/?mno=287954 [Access: December 04, 2023]. doi:10.12816/0004765

AMA (American Medical Association) Style

Al-Baradie R, Lynch S, Borresen J, Krupinski J, Slevin M. CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. Majmaah J Heal Sci. 2013; 1(1): 5-10. doi:10.12816/0004765


Vancouver/ICMJE Style

Al-Baradie R, Lynch S, Borresen J, Krupinski J, Slevin M. CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. Majmaah J Heal Sci. (2013), [cited December 04, 2023]; 1(1): 5-10. doi:10.12816/0004765


Harvard Style

Al-Baradie, R., Lynch, . S., Borresen, . J., Krupinski, . J. & Slevin, . M. (2013) CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. Majmaah J Heal Sci, 1 (1), 5-10. doi:10.12816/0004765


Turabian Style

Al-Baradie, Raid, Stephen Lynch, J Borresen, Jerzy Krupinski, and Mark Slevin. 2013. CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. Majmaah Journal of Health Sciences, 1 (1), 5-10. doi:10.12816/0004765


Chicago Style

Al-Baradie, Raid, Stephen Lynch, J Borresen, Jerzy Krupinski, and Mark Slevin. "CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration." Majmaah Journal of Health Sciences 1 (2013), 5-10. doi:10.12816/0004765


MLA (The Modern Language Association) Style

Al-Baradie, Raid, Stephen Lynch, J Borresen, Jerzy Krupinski, and Mark Slevin. "CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration." Majmaah Journal of Health Sciences 1.1 (2013), 5-10. Print. doi:10.12816/0004765


APA (American Psychological Association) Style

Al-Baradie, R., Lynch, . S., Borresen, . J., Krupinski, . J. & Slevin, . M. (2013) CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration. Majmaah Journal of Health Sciences, 1 (1), 5-10. doi:10.12816/0004765




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