ISSN 1658-645X
 

Original Research (Original Article) 


Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan.

Abstract
Objectives: The current research aimed to evaluate the role of fine needle aspiration biopsy (FNAB) and CD3, CD20 and CD45 in the identification of oral primary diffuse large B-cell lymphoma (DLBCL).

Materials and methods: This is a descriptive clinical study. Ten patients clinically diagnosed as DLBCL in a tertiary level hospital in Qassim, Saudi Arabia; were included. Fine needle aspiration and incisional biopsies were taken from each patient and processed in the appropriate manner. Histopathological confirmation was done using haematoxylin and eosin stained specimens. Other sections were taken for the immune histochemistry using a standard strept-avidin-biotin peroxidase procedure and monoclonal antibodies, including CD3, CD20 and CD45.

Results: The obtained results showed positivity of FNAB in 7 cases and three cases were inconclusive. Strong positive immune reaction was revealed with CD20 and CD45, while CD3 was negative in all studied cases.

Conclusion: These findings indicated the diagnostic significance of FNAB, CD20 CD45 and CD3 in proper diagnosis of oral DLBCL. More research is necessary for predicting the prognostic importance of these molecular markers in oral lymphomas.

Key words: B-cell lymphoma, CD3, CD20, CD45, FNAB


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Abdelraheem R. Elgendy
Articles by Mohamed H. Salama
Articles by S. Karthiga Kannan
on Google
on Google Scholar
Article Statistics
 Viewed: 47
Downloaded: 17
Cited: 0

How to Cite this Article
Pubmed Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci. 2018; 6(2): 10-21.


Web Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. http://www.mjhs-mu.org/?mno=302643524 [Access: November 16, 2018].


AMA (American Medical Association) Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci. 2018; 6(2): 10-21.



Vancouver/ICMJE Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci. (2018), [cited November 16, 2018]; 6(2): 10-21.



Harvard Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan (2018) Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci, 6 (2), 10-21.



Turabian Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. 2018. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah Journal of Health Sciences, 6 (2), 10-21.



Chicago Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. "Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma." Majmaah Journal of Health Sciences 6 (2018), 10-21.



MLA (The Modern Language Association) Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan. "Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma." Majmaah Journal of Health Sciences 6.2 (2018), 10-21. Print.



APA (American Psychological Association) Style

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan (2018) Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah Journal of Health Sciences, 6 (2), 10-21.





Most Viewed Articles
  • Medical Hypnosis – A Poorly Understood Therapeutic Modality
    Riaz Qureshi
    Majmaah J Heal Sci. 2013; 1(1): 1-4
    » Abstract

  • Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats
    Rehan M Asad, Moattar R Rizvi, Sami Waqas, Kamran Afzal
    Majmaah J Heal Sci. 2013; 1(1): 11-17
    » Abstract

  • Upcoming Conferences

    Majmaah J Heal Sci. 2018; 6(1): 90-
    » Abstract

  • Animal Models of Non Cirrhotic Portal Hypertension (NCPH)
    Moattar R Rizvi
    Majmaah J Heal Sci. 2013; 1(1): 58-70
    » Abstract

  • Editorial
    Khalid Bin Mohamed Alabdulwahab
    Majmaah J Heal Sci. 2018; 6(1): -
    » Abstract

  • Roach’s Type II Variant of Sturge – Weber Syndrome: A Case Report
    Saleem Shaikh, Abdur Rahman Al-Atram, Sachdeva Harleen
    Majmaah J Heal Sci. 2013; 1(1): 71-76
    » Abstract

  • Use of FDG-PET/CT for Biological Target Volume Definition in Head and Neck Cancer
    Abdulrahman A Alfuraih
    Majmaah J Heal Sci. 2018; 6(1): 61-82
    » Abstract

  • Prevalence of Hypertriglyceridemia in Patients Attending Primary Health Care Centers in Majmaah, Saudi Arabia
    Fahad Alfhaid
    Majmaah J Heal Sci. 2018; 6(1): 10-16
    » Abstract

  • Parental Knowledge, Attitude and Practice on Antibiotic use for Upper Respiratory Tract Infections in Children
    Khaled Al-Dossari
    Majmaah J Heal Sci. 2013; 1(1): 33-45
    » Abstract

  • Prevalence and Risk Factors of Hypercholesterolemia in Majmaah, Saudi Arabia
    Khalid El Tohami Medani, Mohammed Abdullah Al Mansour, Elsadig Yousif Mohamed, Fahad Alfhaid, Talal Shakhs Alghamdi, Waqas Sami, Sawsan Mustafa Abdalla, Mansour Khater Al Zahrani
    Majmaah J Heal Sci. 2018; 6(1): 34-41
    » Abstract

  • Most Downloaded
  • Relativity of Platelet Count with Automated Cell Counter & Manual Haemocytometer using Peripheral Blood Smear
    Purnendu Sinha, Moattar Raza Rizvi, Ranjay Kumar Choudhary
    Majmaah J Heal Sci. 2014; 2(1): 41-46
    » Abstract

  • Prevalence of Hypertriglyceridemia in Patients Attending Primary Health Care Centers in Majmaah, Saudi Arabia
    Fahad Alfhaid
    Majmaah J Heal Sci. 2018; 6(1): 10-16
    » Abstract

  • Use of FDG-PET/CT for Biological Target Volume Definition in Head and Neck Cancer
    Abdulrahman A Alfuraih
    Majmaah J Heal Sci. 2018; 6(1): 61-82
    » Abstract

  • Prevalence and Risk Factors of Hypercholesterolemia in Majmaah, Saudi Arabia
    Khalid El Tohami Medani, Mohammed Abdullah Al Mansour, Elsadig Yousif Mohamed, Fahad Alfhaid, Talal Shakhs Alghamdi, Waqas Sami, Sawsan Mustafa Abdalla, Mansour Khater Al Zahrani
    Majmaah J Heal Sci. 2018; 6(1): 34-41
    » Abstract

  • Physical Therapy Intervention in Post Stroke Shoulder Subluxation: A Narrative Review
    Mazen Alqahtani
    Majmaah J Heal Sci. 2018; 6(1): 48-60
    » Abstract

  • Editorial
    Khalid Bin Mohamed Alabdulwahab
    Majmaah J Heal Sci. 2018; 6(1): -
    » Abstract

  • Neuromotor Development in a Girl with SERAC 1 Gene Dysfunction from Kingdom of Saudi Arabia: A case study
    Faisal Y. Asiri
    Majmaah J Heal Sci. 2018; 6(1): 42-47
    » Abstract

  • Prevalence of Brucellosis in Hawtat Sudair City, Riyadh Province, Saudi Arabia
    Mohammed Alaidarous
    Majmaah J Heal Sci. 2018; 6(1): 17-25
    » Abstract

  • Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus
    Abdulrahman M. Alamri
    Majmaah J Heal Sci. 2018; 6(1): 26-33
    » Abstract

  • Relationship Between Vitamin-D and Obesity in Pediatric Outpatients, at King Khalid General Hospital, Majmaah, Saudi Arabia
    Fahad K. Aldhafiri
    Majmaah J Heal Sci. 2018; 6(1): 1-9
    » Abstract

  • Most Cited Articles