E-ISSN 1658-8223 | ISSN 1658-645X
 

Original Article 


In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137

Mohammed Alaidarous.

Abstract
Background and Aims:
Helicobacter pylori (H. pylori) is a Gram-negative pathogenic bacterium that causes gastritis in humans. The exact molecular mechanism of most of the non-annotated hypothetical proteins involved in the virulence of H. pylori is yet to be identified. This paper aims to characterize the structure and function of the non-annotated hypothetical protein (HP) HPAG1_0137 from the H. pylori bacterium (strain HPAG1) in silico.
Methods:
We predicted several properties of HPAG1_0137, such as its physicochemical characteristics, secondary and tertiary structures, and functional annotation using different computational tools, followed by structural validation and quality assessment. We also performed virulence, protein crystallization, and active site predictions.
Results:
The study found that HPAG1_0137 has 242 amino acids and an acidic pI and is thermally stable, water-soluble, and distributed in the cytoplasm. Structurally, alpha-helices and random coils are this protein’s most prominent structural components. We found structural models to be highly native and of decent quality.
Conclusions:
This study will facilitate a better understanding of the HPAG1_0137 protein molecular mechanism of action. In addition, it will provide the basis for additional proteomic, genomic data, and structural and pharmacological research for functional and therapeutic potential identification.

Key words: Helicobacter pylori, hypothetical protein, HPAG1_0137 protein, homology modeling, in silico characterization


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mohammed Alaidarous
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Mohammed Alaidarous. In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. Majmaah J Heal Sci. 2023; 11(2): 1-12. doi:10.5455/mjhs.2023.02.002


Web Style

Mohammed Alaidarous. In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. https://www.mjhs-mu.org/?mno=128644 [Access: May 30, 2023]. doi:10.5455/mjhs.2023.02.002


AMA (American Medical Association) Style

Mohammed Alaidarous. In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. Majmaah J Heal Sci. 2023; 11(2): 1-12. doi:10.5455/mjhs.2023.02.002



Vancouver/ICMJE Style

Mohammed Alaidarous. In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. Majmaah J Heal Sci. (2023), [cited May 30, 2023]; 11(2): 1-12. doi:10.5455/mjhs.2023.02.002



Harvard Style

Mohammed Alaidarous (2023) In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. Majmaah J Heal Sci, 11 (2), 1-12. doi:10.5455/mjhs.2023.02.002



Turabian Style

Mohammed Alaidarous. 2023. In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. Majmaah Journal of Health Sciences, 11 (2), 1-12. doi:10.5455/mjhs.2023.02.002



Chicago Style

Mohammed Alaidarous. "In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137." Majmaah Journal of Health Sciences 11 (2023), 1-12. doi:10.5455/mjhs.2023.02.002



MLA (The Modern Language Association) Style

Mohammed Alaidarous. "In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137." Majmaah Journal of Health Sciences 11.2 (2023), 1-12. Print. doi:10.5455/mjhs.2023.02.002



APA (American Psychological Association) Style

Mohammed Alaidarous (2023) In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137. Majmaah Journal of Health Sciences, 11 (2), 1-12. doi:10.5455/mjhs.2023.02.002





Most Viewed Articles
  • Prevalence and Risk Factors of Hypercholesterolemia in Majmaah, Saudi Arabia
    Khalid El Tohami Medani, Mohammed Abdullah Al Mansour, Elsadig Yousif Mohamed, Fahad Alfhaid, Talal Shakhs Alghamdi, Waqas Sami, Sawsan Mustafa Abdalla, Mansour Khater Al Zahrani
    Majmaah J Heal Sci. 2018; 6(1): 34-41
    » Abstract » doi: 10.5455/mjhs.2018.01.006

  • Physical Therapy Intervention in Post Stroke Shoulder Subluxation: A Narrative Review
    Mazen Alqahtani
    Majmaah J Heal Sci. 2018; 6(1): 48-60
    » Abstract » doi: 10.5455/mjhs.2018.01.008

  • Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats
    Rehan M Asad, Moattar R Rizvi, Sami Waqas, Kamran Afzal
    Majmaah J Heal Sci. 2013; 1(1): 11-17
    » Abstract » doi: 10.12816/0004766

  • Parental Knowledge, Attitude and Practice on Antibiotic use for Upper Respiratory Tract Infections in Children
    Khaled Al-Dossari
    Majmaah J Heal Sci. 2013; 1(1): 33-45
    » Abstract » doi: 10.12816/0004769

  • Prevalence of Hypertriglyceridemia in Patients Attending Primary Health Care Centers in Majmaah, Saudi Arabia
    Fahad Alfhaid
    Majmaah J Heal Sci. 2018; 6(1): 10-16
    » Abstract » doi: 10.5455/mjhs.2018.01.003

  • Most Downloaded
  • Wet cupping (Hijama) positively and significantly impacted multiple hematological parameters
    Abdulraheem Alshareef, Ahmad Khalaf Alsaedi, Ahmad Abdulaziz Alnakhli, Abdulrahman Amer Albeladi, Raed Saad AlHejili, Mohammed Siddig Younis
    Majmaah J Heal Sci. 2021; 9(2): 98-112
    » Abstract » doi: 10.5455/mjhs.2021.02.011

  • Medical Waste Management Survey in Primary Health Care Centers, Saudi Arabia
    Eltigani O.M Omer, Ali S. R. Alsubaie
    Majmaah J Heal Sci. 2017; 5(1): 7-22
    » Abstract » doi: 10.5455/mjhs.2017.01.003

  • Physical Therapy Intervention in Post Stroke Shoulder Subluxation: A Narrative Review
    Mazen Alqahtani
    Majmaah J Heal Sci. 2018; 6(1): 48-60
    » Abstract » doi: 10.5455/mjhs.2018.01.008

  • The “Epidemiological Transmission” and “Double-Burden of Disease”: A Focus on Africa
    Asim Abdelmoneim Hussein
    Majmaah J Heal Sci. 2014; 2(2): 3-11
    » Abstract

  • Food Poisoning Knowledge, Attitudes and Practice of Students in Majmaah University
    Saeed Saleh Banawas
    Majmaah J Heal Sci. 2019; 7(2): 1-13
    » Abstract » doi: 10.5455/mjhs.2019.02.002

  • Most Cited Articles
  • Analysing Undergraduate Medical Curricula: Experience from a Saudi Medical College
    Ahmad Saleh Alamro
    Majmaah J Heal Sci. 2019; 7(3): 20-33
    » Abstract » doi: 10.5455/mjhs.2019.03.004
    Cited : 14 times [Click to see citing articles]

  • Prevalence and risk factors of diabetic neuropathy in Qassim, Saudi Arabia
    Amal A Almohisen, Lama M Almuhaysen, Khawlah K Alhatlany, Reham H Alghalth, Ashwaq M Almutairi, Fatmah A Almarzogy, Haneen A Alghasham, Ghaida M Almohaysen
    Majmaah J Heal Sci. 2020; 8(2): 23-31
    » Abstract » doi: 10.5455/mjhs.2020.02.004
    Cited : 3 times [Click to see citing articles]

  • Prevalence & Perception of CAM Usage in Majmaah, Kingdom of Saudi Arabia
    Syed Yousaf Kazmi, Waqas Sami, Saud Ibnsaut Alharbi, Meshaal almeshaal, Anas Alzahrani, Fahad Alyousif, Osama Alenezi
    Majmaah J Heal Sci. 2018; 6(2): 50-61
    » Abstract » doi: 10.5455/mjhs.2018.02.007
    Cited : 3 times [Click to see citing articles]

  • Psychosocial Aspects of Thalassemia and Patient’s Quality of Life: A Narrative Review
    Ali Jawad Alsaad
    Majmaah J Heal Sci. 2020; 8(1): 82-96
    » Abstract » doi: 10.5455/mjhs.2020.01.009
    Cited : 3 times [Click to see citing articles]

  • Physical Therapy Management for Child with Generalized Joint Hypermobility
    Mohamed Sherif Sirajudeen
    Majmaah J Heal Sci. 2020; 8(1): 113-119
    » Abstract » doi: 10.5455/mjhs.2020.01.011
    Cited : 3 times [Click to see citing articles]