Enumeration of NK cells in Patients of Type-II Diabetes Mellitus

RabiaTufail; Nadeem Afzal; Khursheed Javaid; Saba Khaliq; Romeeza Tahir; Afia Abbas; Waqas Latif; Waqas Sami; Abu Zafar

2026, Vol: 14, Issue: 3

14 / 3Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

MANUSCRIPT CHECKLIST_(v2r)_
Title Page

« Previous Article

Original Article
Online Published: 05 Feb 2018

Majmaah J Heal Sci. 2014; 2(2): 23-27

Enumeration of NK cells in Patients of Type-II Diabetes Mellitus

Rabiatufail, Nadeem Afzal, Khursheed Javaid, Saba Khaliq, Romeeza Tahir, Afia Abbas, Waqas Latif, Waqas Sami, Abu Zafar.

Abstract
Background : Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Patients of diabetes mellitus are managed by two basic drug regimens. Generally type-I diabetes is managed by insulin therapy, while type-II diabetes is treated by oral hypoglycemic agents. Natural Killer (NK) cells being an important member of innate immunity have protective and pathogenic roles. A study was designed to enumerate NK cells in diabetes mellitus patients being treated with insulin and oral hypoglycemic therapy.

Material & Methods : It was a cross sectional study that comprised of 80 patients of diabetes mellitus. They were categorized as group-I (on oral hypoglycemic) and group-II (on insulin); 40 patients in each group. For enumeration of NK cells, blood sample was analyzed by four color FACS caliber, using CD16/CD56 PE, and CD45 PerCP monoclonal antibodies.

Result : Mean±SD of percentage of NK cells of patients on oral hypoglycemic agents was high (11.10±5.66) compared to patients on insulin therapy (9.91±5.08) but on comparison it was not statistically significant (p=0.327). Mean±SD of percentage of NK cells of male diabetic patients was high (12.01±5.84) compared to female diabetic patients (9.48±4.83) and on comparison it was statistically significant (p=0.039).

Conclusion : No significant difference was observed in the percentage of NK cells of diabetes mellitus patients on insulin and oral hypoglycemic agents. However, percentage of NK cells was significantly high in male patients as compared to female patients.

Key words: NK cells, NKT cells, T cells, Diabetes mellitus, oral hypoglycemic agents

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by RabiaTufail Articles by Nadeem Afzal Articles by Khursheed Javaid Articles by Saba Khaliq Articles by Romeeza Tahir Articles by Afia Abbas Articles by Waqas Latif Articles by Waqas Sami Articles by Abu Zafar
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Rabiatufail, Afzal N, Javaid K, Khaliq S, Tahir R, Abbas A, Latif W, Sami W, Zafar A. Enumeration of NK cells in Patients of Type-II Diabetes Mellitus. Majmaah J Heal Sci. 2014; 2(2): 23-27.

Web Style

Rabiatufail, Afzal N, Javaid K, Khaliq S, Tahir R, Abbas A, Latif W, Sami W, Zafar A. Enumeration of NK cells in Patients of Type-II Diabetes Mellitus. https://www.mjhs-mu.org/?mno=290209 [Access: June 28, 2026].

AMA (American Medical Association) Style

Rabiatufail, Afzal N, Javaid K, Khaliq S, Tahir R, Abbas A, Latif W, Sami W, Zafar A. Enumeration of NK cells in Patients of Type-II Diabetes Mellitus. Majmaah J Heal Sci. 2014; 2(2): 23-27.

Vancouver/ICMJE Style

Rabiatufail, Afzal N, Javaid K, Khaliq S, Tahir R, Abbas A, Latif W, Sami W, Zafar A. Enumeration of NK cells in Patients of Type-II Diabetes Mellitus. Majmaah J Heal Sci. (2014), [cited June 28, 2026]; 2(2): 23-27.

Harvard Style

Rabiatufail, Afzal, . N., Javaid, . K., Khaliq, . S., Tahir, . R., Abbas, . A., Latif, . W., Sami, . W. & Zafar, . A. (2014) Enumeration of NK cells in Patients of Type-II Diabetes Mellitus. Majmaah J Heal Sci, 2 (2), 23-27.

Turabian Style

Rabiatufail, Nadeem Afzal, Khursheed Javaid, Saba Khaliq, Romeeza Tahir, Afia Abbas, Waqas Latif, Waqas Sami, and Abu Zafar. 2014. Enumeration of NK cells in Patients of Type-II Diabetes Mellitus. Majmaah Journal of Health Sciences, 2 (2), 23-27.

Chicago Style

Rabiatufail, Nadeem Afzal, Khursheed Javaid, Saba Khaliq, Romeeza Tahir, Afia Abbas, Waqas Latif, Waqas Sami, and Abu Zafar. "Enumeration of NK cells in Patients of Type-II Diabetes Mellitus." Majmaah Journal of Health Sciences 2 (2014), 23-27.

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

About Majmaah Journal of Health Sciences

Contact Information

How to cite this article